An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence
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چکیده
منابع مشابه
An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence.
In addition to acting as a transcriptional cofactor for p53, ASPP1 has been shown to function in the cytoplasm to regulate the nuclear localization and activity of YAP/TAZ. We show here that the ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability of p53 to induce p21, cell-cycle arrest and senescence. ASPP1 expression peaks in S-phase, and dow...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2011
ISSN: 0261-4189
DOI: 10.1038/emboj.2011.402